Kisspeptin Pen

As research shows

Kisspeptin (also known as metastin) is a naturally occurring neuroendocrine peptide that plays a pivotal role in human reproduction by stimulating gonadotropin-releasing hormone (GnRH) secretion. This small peptide binds to the GPR54 receptor in the hypothalamus, triggering pulsatile GnRH release and downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Originally identified as a metastasis-suppressor gene product, kisspeptin has become a major focus in reproductive endocrinology. This educational protocol presents a once-daily subcutaneous approach for research use.

Key benefits

• Physiological Sex Hormone Stimulation: Increases endogenous testosterone and estrogen levels by amplifying the body’s own LH/FSH signals without suppressing the HPG axis.
• Fertility Restoration: Shows promise in functional hypothalamic amenorrhea by rekindling GnRH/LH pulsatility and resuming menstrual cycles.
• IVF Ovulation Trigger: Can induce robust LH surge to mature oocytes while potentially lowering the risk of ovarian hyperstimulation syndrome compared to traditional hCG triggers.
• Safety Profile: Generally well tolerated; occasional mild injection-site reactions (redness/itch) may occur with subcutaneous administration.